ClinicalReTrial: A Self-Evolving AI Agent for Clinical Trial Protocol Optimization

By: Sixue Xing, Xuanye Xia, Kerui Wu, Meng Jiang, Jintai Chen, Tianfan Fu

Published: 2026-01-05

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Abstract

This research introduces ClinicalReTrial, a self-evolving AI agent designed to optimize clinical trial protocols. This agent leverages AI and multiagent systems to enhance the efficiency and effectiveness of clinical trials, which is crucial for accelerating drug development and improving patient outcomes. The paper contributes to the field of medical AI by proposing an autonomous system capable of iteratively refining complex procedural documents in a high-stakes domain.

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ClinicalReTrial: A Self-Evolving AI Agent for Clinical Trial Protocol Optimization | ArXiv Intelligence